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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 1
2008 2
2009 1
2010 1
2011 2
2012 6
2013 2
2014 2
2015 2
2018 1
2019 1
2020 1
2021 3
2023 1
2024 1

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21 results

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Page 1
ORMDL3 and allergic asthma: From physiology to pathology.
James B, Milstien S, Spiegel S. James B, et al. J Allergy Clin Immunol. 2019 Sep;144(3):634-640. doi: 10.1016/j.jaci.2019.07.023. Epub 2019 Jul 31. J Allergy Clin Immunol. 2019. PMID: 31376405 Free PMC article. Review.
There is a strong genetic component to asthma, and numerous genome-wide association studies have identified ORM1 (yeast)-like protein 3 (ORMDL3) as a gene associated with asthma susceptibility. ...Finally, we briefly survey the utility of sphingolipid metabol …
There is a strong genetic component to asthma, and numerous genome-wide association studies have identified ORM1 (yeast)-like …
Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma.
Wu H, Romieu I, Sienra-Monge JJ, Li H, del Rio-Navarro BE, London SJ. Wu H, et al. Allergy. 2009 Apr;64(4):629-35. doi: 10.1111/j.1398-9995.2008.01912.x. Epub 2008 Dec 30. Allergy. 2009. PMID: 19133921 Free PMC article.
BACKGROUND: A genome-wide association study identified ORM1-like 3 (orosomucoid 1-like 3, ORMDL3) as an asthma candidate gene. Single nucleotide polymorphisms (SNPs) in the region including ORMDL3 on chromosome 17q21 were related to childhood asthma risk and …
BACKGROUND: A genome-wide association study identified ORM1-like 3 (orosomucoid 1-like 3, ORMDL3) as an asthma candidate gene. …
The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis.
Zhao CN, Fan Y, Huang JJ, Zhang HX, Gao T, Wang C, Wang T, Hou LF. Zhao CN, et al. Allergy Asthma Immunol Res. 2015 Mar;7(2):175-85. doi: 10.4168/aair.2015.7.2.175. Epub 2014 Dec 18. Allergy Asthma Immunol Res. 2015. PMID: 25729625 Free PMC article.
Recent reports suggest that GSDMB and ORMDL3 are associated with asthma in several populations. However, genetic association studies that examined the association of GSDMB and ORMDL3 gene variants with asthma showed conflicting results. To assess whether combined ev …
Recent reports suggest that GSDMB and ORMDL3 are associated with asthma in several populations. However, genetic association studies …
A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.
Stein MM, Thompson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Morin A, Washington C 3rd, Nicolae D, Bønnelykke K, Ober C. Stein MM, et al. J Allergy Clin Immunol. 2018 Sep;142(3):749-764.e3. doi: 10.1016/j.jaci.2017.12.974. Epub 2018 Jan 4. J Allergy Clin Immunol. 2018. PMID: 29307657 Free PMC article. Review.
Chromosome 17q12-21 remains the most highly replicated and significant asthma locus. Genotypes in the core region defined by the first genome-wide association study correlate with expression of 2 genes, ORM1-like 3 (ORMDL3) and gasdermin B (GSDMB), making these prim …
Chromosome 17q12-21 remains the most highly replicated and significant asthma locus. Genotypes in the core region defined by the firs …
Intrauterine Smoke Exposure, microRNA Expression during Human Lung Development, and Childhood Asthma.
Rosenberg L, Liu C, Sharma R, Wood C, Vyhlidal CA, Gaedigk R, Kho AT, Ziniti JP, Celedón JC, Tantisira KG, Weiss ST, McGeachie MJ, Kechris K, Sharma S. Rosenberg L, et al. Int J Mol Sci. 2023 Apr 23;24(9):7727. doi: 10.3390/ijms24097727. Int J Mol Sci. 2023. PMID: 37175432 Free PMC article.
We additionally evaluated whether miRNAs were associated with asthma and allergy outcomes in a cohort of childhood asthma. We profiled pseudoglandular lung miRNA in n = 298 samples, 139 (47%) of which had evidence of IUS exposure. Of 515 miRNAs, 25 were significantl …
We additionally evaluated whether miRNAs were associated with asthma and allergy outcomes in a cohort of childhood asthma. We …
Association of ORMDL3, STAT6 and TBXA2R gene polymorphisms with asthma.
Kavalar MS, Balantic M, Silar M, Kosnik M, Korosec P, Rijavec M. Kavalar MS, et al. Int J Immunogenet. 2012 Feb;39(1):20-5. doi: 10.1111/j.1744-313X.2011.01051.x. Epub 2011 Oct 21. Int J Immunogenet. 2012. PMID: 22017802
One of the most replicated asthma candidate genes is ORM1-like 3 (Saccharomyces cerevisiae) (ORMDL3), which has been associated with childhood asthma susceptibility. ...The ORMDL3 polymorphism rs4795405 was suggestively associated with asthma risk. Fur …
One of the most replicated asthma candidate genes is ORM1-like 3 (Saccharomyces cerevisiae) (ORMDL3), which has been associate …
Comprehensive functional annotation of susceptibility variants associated with asthma.
Gautam Y, Afanador Y, Ghandikota S, Mersha TB. Gautam Y, et al. Hum Genet. 2020 Aug;139(8):1037-1053. doi: 10.1007/s00439-020-02151-5. Epub 2020 Apr 2. Hum Genet. 2020. PMID: 32240371 Free PMC article.
We present a comprehensive genome-wide non-coding variant prioritization scheme followed by validation using Pyrosequencing and TaqMan assays in asthma. We implemented a composite Functional Annotation Score (cFAS) to investigate over 32,000 variants consisting of 1525 GWA …
We present a comprehensive genome-wide non-coding variant prioritization scheme followed by validation using Pyrosequencing and TaqMan assay …
Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways.
Bugajev V, Paulenda T, Utekal P, Mrkacek M, Halova I, Kuchar L, Kuda O, Vavrova P, Schuster B, Fuentes-Liso S, Potuckova L, Smrz D, Cernohouzova S, Draberova L, Bambouskova M, Draber P. Bugajev V, et al. J Lipid Res. 2021;62:100121. doi: 10.1016/j.jlr.2021.100121. Epub 2021 Sep 22. J Lipid Res. 2021. PMID: 34560079 Free PMC article.
Leukotrienes (LTs) and sphingolipids are critical lipid mediators participating in numerous cellular signal transduction events and developing various disorders, such as bronchial hyperactivity leading to asthma. Enzymatic reactions initiating production of these lipid med …
Leukotrienes (LTs) and sphingolipids are critical lipid mediators participating in numerous cellular signal transduction events and developi …
Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population.
Yang FF, Huang Y, Li QB, Dai JH, Fu Z. Yang FF, et al. Genet Mol Res. 2012 Dec 19;11(4):4646-53. doi: 10.4238/2012.October.19.1. Genet Mol Res. 2012. PMID: 23096927 Free article.
Single nucleotide polymorphism (SNP)-based genome-wide association studies have revealed that polymorphisms of the ORM1-like 3 (ORMDL3) gene are associated with childhood asthma. We investigated genetic associations of SNPs in and around the ORMDL3 gene with childho …
Single nucleotide polymorphism (SNP)-based genome-wide association studies have revealed that polymorphisms of the ORM1-like 3 (ORMDL …
Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Li X, et al. J Allergy Clin Immunol. 2012 Oct;130(4):861-8.e7. doi: 10.1016/j.jaci.2012.04.041. Epub 2012 Jun 12. J Allergy Clin Immunol. 2012. PMID: 22694930 Free PMC article.
BACKGROUND: Genome-wide association studies (GWASs) of asthma have consistently implicated the ORM1-like 3 and gasdermin B (ORMDL3-GSDMB), IL33, IL-1 receptor-like 1 and IL-18 receptor 1 (IL1RL1-IL18R1), RAD50-IL13, thymic stromal lymphopoietin and WD repeat domain …
BACKGROUND: Genome-wide association studies (GWASs) of asthma have consistently implicated the ORM1-like 3 and gasdermin B (OR …
21 results